Wasco County is one of the 36 counties in the U.S. state of Oregon. As of the 2020 census, the population was 25,213. Its county seat is The Dalles. The county is named for a local tribe of Native Americans, the Wasco, a Chinook tribe that live on the south side of the Columbia River.

Celilo Falls on the Columbia River served as a gathering place and major trading center for the local Native Americans, including the Wasco, Paiute, and Warm Springs tribes, for thousands of years. These rapids came to be named Les Grandes Dalles de la Columbia or "The Great Falls of the Columbia" by the French Canadian fur traders.

The Dalles initially served as a way station on the Oregon Trail as it approached the Willamette Valley. The construction of the Barlow Road over the Cascade Range in 1845, and the Donation Land Claim Act of 1850 encouraged families to settle in the area. Over the following years, Wasco County was a major transportation hub for both river and inland traffic.

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Wasco County is home to the northern end of the Oregon Outback Trail which begins in Klamath Falls and winds through the Oregon countryside for 360 miles to the Columbia River. This trail is well known for bikepacking adventures which take five or six days.

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